
RHR: Why Microglia Are Key to Brain Health, with Dr. Perlmutter
Your brain’s immune cells don’t just react to bad sleep — they listen to your gut, your gums, and your stress. Here’s how microglial priming works and what quiets it.

Your brain’s immune cells don’t just react to bad sleep — they listen to your gut, your gums, and your stress. Here’s how microglial priming works and what quiets it.

The forgetfulness and mental static of menopause has a biological driver: declining estradiol reshaping brain energy and signaling. Not a character flaw, not just stress.

The word-finding slips and mental static after 40 may come from primed microglia, not just hormones — and that changes what actually helps.

The menopausal brain is physically changing — and most doctors are looking in the wrong direction.

The menopausal brain isn’t broken. It’s recalibrating — and the science behind why you feel foggy, anxious, and unlike yourself is finally catching up.

The immune pathway from gut inflammation to brain fog runs through cytokines and microglial activation — and it’s more direct than you think.

Lion’s Mane doesn’t just mask brain fog — its active compounds cross the blood-brain barrier and stimulate nerve growth factor to actually rebuild damaged neural infrastructure.

Why you can’t think straight after 40 You used to walk into a room and know why you were there. Now you stand in the doorway, staring at the wall, trying to remember if you came for your phone, your keys, or something you can’t name at all. ...
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